Selected Publications
Vermehren-Schmaedick, A.; Huang, J.Y.; Levinson, M.; Pomaville, M.B.; Reed, S.; Bellus, G.A.; Gilbert, F.; Keren, B.; Heron, D.; Haye, D.; Janello, C.; Makowski, C.; Danhauser, K.; Fedorov, L.M.; Haack, T.B.; Wright, K.M.; Cohen, M.S. (2021) Characterization of PARP6 Function in Knockout Mice and Patients with Developmental Delay. Cells PDF
Justina Šileikytė, Sunil Sundalam, Larry L. David, and Michael S. Cohen (2021) Chemical Proteomics Approach for Profiling the NAD Interactome. Journal of the American Chemical Society PDF
Rodriguez KM, Buch-Larsen SC, Kirby IT, Siordia IR, Hutin D, Rasmussen M, Grant DM, David LL, Matthews J, Nielsen ML, Cohen MS. Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets. Elife. 2021 Jan 21 PDF
Daniel J. Sanderson & Michael S. Cohen (2020) Mechanisms governing PARP expression, localization, and activity in cells, Critical Reviews in Biochemistry and Molecular Biology PDF
Cohen MS. Interplay between compartmentalized NAD+ synthesis and consumption: a focus on the PARP family. Genes Dev. (2020) Mar 1 PDF
Sileikyte, J., Devereaux, J., de Jong, L., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M., and Cohen, M.S. “Second generation inhibitors of the mitochondrial permeability transition pore with improved plasma stability,” ChemMedChem, online August (2019).
Rational Design of Cell-Active Inhibitors of PARP10. Rory K. Morgan, Ilsa T. Kirby, Anke Vermehren-Schmaedick, Kelsie Rodriguez, and Michael S. Cohen. ACS Med Chem Let (2019). PDF
A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity. Ilsa T. Kirby, Ana Kojic and Moriah R. Arnold, Ann-Gerd Thorsell, Tobias Karlberg, Anke Vermehren-Schmaedick, Raashi Sreenivasan, Carsten Schultz, Herwig Schüler, and Michael S. Cohen. Cell Chemical Biology, 25, 1–7 (2018). PDF
Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14) Carter-O’Connell, I.O., Vermehren-Schmaedick, A, Jin, H, Haihong Jin, Morgan, R.K., David, L.L., Cohen, M.S., ACS Chemical Biology, Article ASAP (2018). PDF
Kirby, I.T. and Cohen, M.S. "Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapuetics." Current Topics in Microbiology and Immunology, (2018). PDF
Cohen, M.S. and Chang, P. “Insights into the biogenesis, function, and regulation of ADP-ribosylation,” Nature Chemical Biology, 14, 236 (2018).
Cohen, M.S., Stewart, M.L., Goodman, R.H., Cambronne, X.A. “Methods for using a genetically encoded fluorescent biosensor to monitor nuclear NAD,” Methods in Molecular Biology, 1813, 391 (2018).
Kirby, I.T., Morgan, R.K., and Cohen, M.S. “A simple, sensitive, and generalizable plate assay for screening PARP inhibitors,” Methods in Molecular Biology, 1813, 245 (2018).
Morgan, R.K, and Cohen, M.S. “Detecting protein ADP-ribosylation using a clickable aminooxy probe,” Methods in Molecular Biology, 1601, 71 (2017). PDF
Cohen, M.S. “Axon Degeneration: Too Much NMN is Actually Bad,” Current Biology, 27, R310 (2017).
Thorsell, A.G., Ekblad, T. Karlberg, T., Low, M., Pinto, A.F., Tresaugues, L., Moche, M., Cohen, M.S., and Schuler, H. “Structural Basis for Potency and Promiscuity in Poly)ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors,” Journal of Medicinal Chemistry, 60, 1262 (2017).
Cambronne, X.A.*,Stewart, M.L., Kim, D., Jones-Brunette, A.M., Morgan, R.K., Farrens, D.L.,Cohen, M.S.*, Goodman, R.H. "Biosensor reveals multiple sources for mitochondrial NAD+," Science 352, 1474 (2016). PDF
*corresponding authors
Barrett R.M., Liu H.W., Jin H., Goodman R.H., and Cohen M.S. "Cell-specific Profiling of Nascent Proteomes Using Orthogonal Enzyme-mediated Puromycin Incorporation," ACS Chemical Biology, 11, 1532 (2016). PDF
Carter-O'Connell, I.O., Jin H., Morgan, R.K., David, L.L., and Cohen. M.S. "Decoding the MARylome: A Chemical Genetic Strategy for Identifying Family-member Specific Targets of Mono-ARTDs," Cell Reports, 14, 621 (2016). PDF
Huang, J., Wang, K., Vermehren-Schmaedick, A., Adelman, J., Cohen, M.S. "PARP6 is a regulator of Hippocampal Dendritic Morphogenesis," Scientific Reports, 6, 18512 (2016). PDF
Morgan, R.K., Carter-O'Connell, I.O., and Cohen, M.S. "Selective inhibition of PARP10 using a chemical genetics strategy," Bioorganic Medicinal Chemistry Letters, 25, 4770 (2015). PDF
Morgan, R.K. and Cohen, M.S. "A Clickable Aminooxy Probe for Monitoring Cellular ADP-ribosylation," ACS Chemical Biology, 10, 1778 (2015).
Carter-O'Connell, I.O. and Cohen, M.S. "Identifying Direct Protein Targets of Engineered Poly-ADP-ribose Polymerases (PARPs) Using Modified Nicotinamide Adenine Dinucleotide Reporters," Current Protocols in Chemical Biology, 7, 121 (2015). PDF
Carter-O'Connell IO, Jin H, Morgan RK, David LL, Cohen MS. "Engineering the substrate specificity of ADP-ribosyltransferases for identifying direct protein targets," Journal of the American Chemical Society, 136, 5201 (2014). PDF
Justina Šileikytė, Sunil Sundalam, Larry L. David, and Michael S. Cohen (2021) Chemical Proteomics Approach for Profiling the NAD Interactome. Journal of the American Chemical Society PDF
Rodriguez KM, Buch-Larsen SC, Kirby IT, Siordia IR, Hutin D, Rasmussen M, Grant DM, David LL, Matthews J, Nielsen ML, Cohen MS. Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets. Elife. 2021 Jan 21 PDF
Daniel J. Sanderson & Michael S. Cohen (2020) Mechanisms governing PARP expression, localization, and activity in cells, Critical Reviews in Biochemistry and Molecular Biology PDF
Cohen MS. Interplay between compartmentalized NAD+ synthesis and consumption: a focus on the PARP family. Genes Dev. (2020) Mar 1 PDF
Sileikyte, J., Devereaux, J., de Jong, L., Schiavone, M., Jones, K., Nilsen, A., Bernardi, P., Forte, M., and Cohen, M.S. “Second generation inhibitors of the mitochondrial permeability transition pore with improved plasma stability,” ChemMedChem, online August (2019).
Rational Design of Cell-Active Inhibitors of PARP10. Rory K. Morgan, Ilsa T. Kirby, Anke Vermehren-Schmaedick, Kelsie Rodriguez, and Michael S. Cohen. ACS Med Chem Let (2019). PDF
A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity. Ilsa T. Kirby, Ana Kojic and Moriah R. Arnold, Ann-Gerd Thorsell, Tobias Karlberg, Anke Vermehren-Schmaedick, Raashi Sreenivasan, Carsten Schultz, Herwig Schüler, and Michael S. Cohen. Cell Chemical Biology, 25, 1–7 (2018). PDF
Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14) Carter-O’Connell, I.O., Vermehren-Schmaedick, A, Jin, H, Haihong Jin, Morgan, R.K., David, L.L., Cohen, M.S., ACS Chemical Biology, Article ASAP (2018). PDF
Kirby, I.T. and Cohen, M.S. "Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapuetics." Current Topics in Microbiology and Immunology, (2018). PDF
Cohen, M.S. and Chang, P. “Insights into the biogenesis, function, and regulation of ADP-ribosylation,” Nature Chemical Biology, 14, 236 (2018).
Cohen, M.S., Stewart, M.L., Goodman, R.H., Cambronne, X.A. “Methods for using a genetically encoded fluorescent biosensor to monitor nuclear NAD,” Methods in Molecular Biology, 1813, 391 (2018).
Kirby, I.T., Morgan, R.K., and Cohen, M.S. “A simple, sensitive, and generalizable plate assay for screening PARP inhibitors,” Methods in Molecular Biology, 1813, 245 (2018).
Morgan, R.K, and Cohen, M.S. “Detecting protein ADP-ribosylation using a clickable aminooxy probe,” Methods in Molecular Biology, 1601, 71 (2017). PDF
Cohen, M.S. “Axon Degeneration: Too Much NMN is Actually Bad,” Current Biology, 27, R310 (2017).
Thorsell, A.G., Ekblad, T. Karlberg, T., Low, M., Pinto, A.F., Tresaugues, L., Moche, M., Cohen, M.S., and Schuler, H. “Structural Basis for Potency and Promiscuity in Poly)ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors,” Journal of Medicinal Chemistry, 60, 1262 (2017).
Cambronne, X.A.*,Stewart, M.L., Kim, D., Jones-Brunette, A.M., Morgan, R.K., Farrens, D.L.,Cohen, M.S.*, Goodman, R.H. "Biosensor reveals multiple sources for mitochondrial NAD+," Science 352, 1474 (2016). PDF
*corresponding authors
- Featured in: Perspectives: Science, 352, 1396 (2017) and Research Highlights: Nature Methods, 13, 610 (2017)
Barrett R.M., Liu H.W., Jin H., Goodman R.H., and Cohen M.S. "Cell-specific Profiling of Nascent Proteomes Using Orthogonal Enzyme-mediated Puromycin Incorporation," ACS Chemical Biology, 11, 1532 (2016). PDF
Carter-O'Connell, I.O., Jin H., Morgan, R.K., David, L.L., and Cohen. M.S. "Decoding the MARylome: A Chemical Genetic Strategy for Identifying Family-member Specific Targets of Mono-ARTDs," Cell Reports, 14, 621 (2016). PDF
Huang, J., Wang, K., Vermehren-Schmaedick, A., Adelman, J., Cohen, M.S. "PARP6 is a regulator of Hippocampal Dendritic Morphogenesis," Scientific Reports, 6, 18512 (2016). PDF
Morgan, R.K., Carter-O'Connell, I.O., and Cohen, M.S. "Selective inhibition of PARP10 using a chemical genetics strategy," Bioorganic Medicinal Chemistry Letters, 25, 4770 (2015). PDF
Morgan, R.K. and Cohen, M.S. "A Clickable Aminooxy Probe for Monitoring Cellular ADP-ribosylation," ACS Chemical Biology, 10, 1778 (2015).
Carter-O'Connell, I.O. and Cohen, M.S. "Identifying Direct Protein Targets of Engineered Poly-ADP-ribose Polymerases (PARPs) Using Modified Nicotinamide Adenine Dinucleotide Reporters," Current Protocols in Chemical Biology, 7, 121 (2015). PDF
Carter-O'Connell IO, Jin H, Morgan RK, David LL, Cohen MS. "Engineering the substrate specificity of ADP-ribosyltransferases for identifying direct protein targets," Journal of the American Chemical Society, 136, 5201 (2014). PDF
- Featured in: Perspectives: F1000 prime and Chemistry and Engineering News “concentrates.”
